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Agents where the main therapeutic effect is mediated by negative modulation of histamine receptors are termed antihistamines; other agents may have antihistaminergic action but are not true antihistamines.

In common use, the term "antihistamine" refers only to H In type I hypersensitivity allergic reactions, an allergen (a type of antigen) interacts with and cross-links surface Ig E antibodies on mast cells and basophils.

antihistamines remain the mainstay of treatment for chronic urticaria.

If these agents are ineffective, higher dosages may be tried (up to four times the standard recommended dosage), or other agents may be substituted (see below).

The review covers most of the methods described for the analysis of cetirizine (CTZ), ebastine (EBS), fexofenadine (FXD), ketotifen (KET) and loratadine (LOR) in pure forms, in different pharmaceutical dosage forms and in biological fluids. Sedation and impairment of performance are concerns when sedating antihistamines are used, but these adverse effects may diminish after 1-2 weeks of therapy.Many patients find that pruritus is less troublesome during the day but is maximized at night, when there are fewer distractions.Antihistamines are used in the treatment of allergic reactions, colds, hay fever, hives, and insect bites and stings.Some antihistamines may also be helpful in reducing anxiety, inducing sleep, or at preventing or treating motion sickness.

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